Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.56 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.50 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722148 | 0.80 | LMNA (0.50) | LMNACYP19A1VCAM1CYP2C19HTT | |
| SCHEMBL26547989 | 0.78 | KDM4E (0.60) | LMNACYP19A1VCAM1ALDH1A1MAPT | |
| SCHEMBL4661775 | 0.77 | CA2 (0.76) | LMNACYP19A1VCAM1KEAP1CA1 | |
| SCHEMBL4968417 | 0.77 | FFAR4 (0.71) | LMNAVCAM1KEAP1CA1CA2 | |
| SCHEMBL4661602 | 0.77 | CYP19A1 (0.82) | CYP19A1VCAM1KEAP1CA1CA2 | |
| SCHEMBL4661669 | 0.75 | CA12 (0.66) | LMNACYP19A1VCAM1KEAP1CA12 | |
| SCHEMBL27898111 | 0.74 | VCAM1 (0.83) | LMNAVCAM1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28557716 | 0.74 | ALDH1A1 (0.59) | LMNAVCAM1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4663044 | 0.74 | KEAP1 (0.76) | LMNACYP19A1KEAP1CA1CA2 | |
| SCHEMBL2857133 | 0.73 | LMNA (0.52) | LMNAVCAM1CA1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | RB1, CYP2C19, ADRB3 | LMNA 1900/4885CYP19A1 1100/4885VCAM1 4688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.