Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 17/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722182 | 0.82 | CNR2 (0.69) | CNR2 | |
| SCHEMBL5722233 | 0.80 | CNR2 (0.59) | GNRHRMEN1ALDH1A1MAPTTHRB | |
| SCHEMBL5722219 | 0.79 | CNR2 (0.65) | CNR2 | |
| SCHEMBL4965783 | 0.78 | F2 (0.46) | CNR2 | |
| SCHEMBL4967696 | 0.71 | F2 (0.48) | ALDH1A1CNR2 | |
| SCHEMBL4662893 | 0.71 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5722234 | 0.71 | CNR2 (0.58) | CNR2 | |
| SCHEMBL5521048 | 0.69 | CNR2 (0.62) | CNR2 | |
| SCHEMBL30075090 | 0.69 | ALDH1A1 (0.59) | GNRHRLMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL5722202 | 0.69 | CNR2 (0.57) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |