Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112643 | 0.95 | THRA (0.44) | THRATHRBNR2E1MRGPRX4MME | |
| SCHEMBL5116750 | 0.92 | THRB (0.42) | THRATHRBPTGER1DHODHFFAR1 | |
| SCHEMBL5722658 | 0.92 | THRA (0.39) | THRATHRBNR2E1MRGPRX4MME | |
| SCHEMBL5722697 | 0.88 | THRA (0.46) | THRATHRBMRGPRX4FFAR4FFAR1 | |
| SCHEMBL5119332 | 0.86 | THRB (0.43) | THRATHRBNR2E1MMEACE | |
| SCHEMBL5107973 | 0.86 | THRA (0.43) | THRATHRBMRGPRX4MMEACE | |
| SCHEMBL4930958 | 0.85 | THRA (0.44) | THRATHRBMRGPRX4MMEACE | |
| SCHEMBL5110521 | 0.85 | MRGPRX4 (0.39) | NR2E1MRGPRX4MMEACECPA1 | |
| SCHEMBL4928651 | 0.85 | THRB (0.46) | THRATHRBMRGPRX4MMEACE | |
| SCHEMBL5722513 | 0.84 | THRA (0.35) | THRATHRBNR2E1MRGPRX4MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |