Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 3/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.32 |
| ▸ | RELA | Q04206 | 3/20 | 0.32 |
| ▸ | XPO1 | O14980 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722653 | 0.92 | THRA (0.41) | THRATHRBNR2E1MRGPRX4PTGER1 | |
| SCHEMBL5112643 | 0.87 | THRA (0.44) | THRATHRBNR2E1MRGPRX4PTGER1 | |
| SCHEMBL5116750 | 0.83 | THRB (0.42) | THRATHRBPTGER1TACR1MEN1 | |
| SCHEMBL5722697 | 0.81 | THRA (0.46) | THRATHRBMRGPRX4 | |
| SCHEMBL5722480 | 0.80 | ALDH1A1 (0.37) | THRATHRBPTGER1KDM4EMEN1 | |
| SCHEMBL5119332 | 0.79 | THRB (0.43) | THRATHRBNR2E1TACR1ALDH1A1 | |
| SCHEMBL5722499 | 0.79 | THRA (0.35) | THRATHRBPTGER1KDM4EMEN1 | |
| SCHEMBL5116916 | 0.78 | THRB (0.50) | THRATHRBNR2E1ALDH1A1LMNA | |
| SCHEMBL5717851 | 0.78 | THRA (0.37) | THRATHRBTACR1KDM4EMEN1 | |
| SCHEMBL5107973 | 0.77 | THRA (0.43) | THRATHRBMRGPRX4PTGER1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |