Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134588 | 0.90 | TSHR (0.54) | HSPA5KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL4731949 | 0.82 | HSPA5 (0.64) | HSPA5KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL5724328 | 0.82 | HPGD (0.61) | HSPA5KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL28473820 | 0.81 | HSPA5 (0.57) | HSPA5KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL10604923 | 0.81 | MAPT (0.46) | KDM4EALDH1A1HPGDTSHRMAPT | |
| SCHEMBL3461538 | 0.79 | LMNA (0.50) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3461564 | 0.79 | MAPK8 (0.49) | KDM4EALDH1A1HPGDTSHRMAPT | |
| SCHEMBL8032460 | 0.79 | MMP2 (0.49) | KDM4EALDH1A1HPGDTSHRMAPT | |
| SCHEMBL5178408 | 0.78 | KDM4E (0.41) | HSPA5KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL49745 | 0.78 | HSPA5 (1.00) | HSPA5KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |