Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 11/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 8/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desmetramadol SCHEMBL12125413 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| Desmetramadol SCHEMBL57246 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL4396391 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL4396389 | 1.00 | OPRM1 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL2518899 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL7882257 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| Desmetramadol SCHEMBL2410234 | 0.99 | OPRM1 (0.97) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948058 | 0.93 | OPRM1 (0.95) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948069 | 0.92 | SLC6A4 (1.00) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 | |
| O-Desmethyl Tramadol SCHEMBL13948086 | 0.91 | SLC6A4 (0.84) | OPRM1SLC6A4SLC6A2OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265044-A1 | SALT OF DEMETHYL TRAMADOL AND USE THEREOF | NANJING NORATECH PHARMACEUTICAL CO., LTD. (CN) | 2023-08-24 | — | — | US | disclosed |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | R L FINECHEM PRIVATE LIMITED (IN) | 2020-09-22 | — | — | US | disclosed |
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L FINECHEM PRIVATE LIMITED (IN) | 2020-07-23 | — | — | US | disclosed |
| US-10416175-B2 | Opioid detection | RANDOX LABORATORIES LIMITED (GB) | 2019-09-17 | — | — | US | disclosed |
| WO-2019053494-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | R L FINE CHEM PRIVATE LIMITED (IN) | 2019-03-21 | — | — | WO | disclosed |
| EP-3296289-A2 | PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS | Sunovion Pharmaceuticals Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-20170204050-A1 | PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REPUTAKE INHIBITORS | SUNOVION PHARMACEUTICALS INC. | 2017-07-20 | — | — | US | disclosed |
| US-20170204050-A1 | PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REPUTAKE INHIBITORS | SUNOVION PHARMACEUTICALS INC. | 2017-07-20 | — | — | US | disclosed |
| EP-3185015-A1 | OPIOID DETECTION | Randox Laboratories Ltd. (GB) | 2017-06-28 | — | — | EP | disclosed |
| EP-1988398-A1 | Immunoassay for tramadol and its major metabolites | Randox Laboratories Ltd. (GB) | 2008-11-05 | — | — | EP | disclosed |
| CN-1176902-C | New esters derived from substituted phenyl-cyclohexyl compounds | ά��ʵ��������˾ | 2004-11-24 | — | — | CN | disclosed |
| EP-1069106-B1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0799819-B1 | 1-Dimethylaminomethyl 2-phenyl cycloalk-2-ene derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| CN-1325377-A | Novel esters derived from substituted phenyl-cyclohexyl compounds | VITA INVEST SA (ES) | 2001-12-05 | — | — | CN | disclosed |
| EP-1069106-A2 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| EP-0983994-A2 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | Grünenthal GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0753506-B1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 1999-08-18 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |
| EP-0753506-A1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231536-A1 | A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF | CYP3A7, TET1, CYP3A4 | OPRM1 84/4885SLC6A4 123/4885SLC6A2 109/4885 |
| US-10416175-B2 | Opioid detection | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885SLC6A4 432/4885SLC6A2 630/4885 |
| US-20230265044-A1 | SALT OF DEMETHYL TRAMADOL AND USE THEREOF | TPMT, TET1, KDM7A | OPRM1 96/4885SLC6A4 87/4885SLC6A2 74/4885 |
| US-10781163-B2 | Process for preparation of O-Desmethyltramadol and salts thereof | TET1, TET2, TET3 | OPRM1 144/4885SLC6A4 160/4885SLC6A2 151/4885 |
| US-20170204050-A1 | PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REPUTAKE INHIBITORS | SLC18A2, SLC18A3, SLC6A2 | OPRM1 171/4885SLC6A4 4/4885SLC6A2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.