Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725518 | 0.86 | ENO1 (0.31) | LMNASMN1; SMN2 | |
| SCHEMBL8348647 | 0.86 | GAA (0.38) | GAALMNASMN1; SMN2HDAC4HDAC6 | |
| SCHEMBL5726678 | 0.79 | — | — | |
| SCHEMBL5724965 | 0.78 | CHRM3 (0.36) | LMNASMN1; SMN2 | |
| SCHEMBL5726425 | 0.78 | GAA (0.41) | GAALMNASMN1; SMN2HDAC4HDAC6 | |
| SCHEMBL5724985 | 0.78 | GAA (0.41) | GAALMNASMN1; SMN2HDAC4HDAC6 | |
| SCHEMBL7976972 | 0.69 | DHODH (0.37) | LMNA | |
| SCHEMBL5724973 | 0.65 | CHRM3 (0.36) | — | |
| SCHEMBL24818982 | 0.65 | GAA (0.51) | GAABTK | |
| SCHEMBL764580 | 0.65 | GAA (0.51) | GAABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812318-B1 | 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2006-02-08 | — | — | EP | disclosed |
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |