SCHEMBL7976972

SCHEMBL7976972

CNC1CCCc2onc(OCOC(=O)c3ccccc3)c21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ATM Q13315 1/20 0.37
LMNA P02545 2/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNA5 P30532 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
CARM1 Q86X55 1/20 0.35
PRMT6 Q96LA8 1/20 0.35
POLB P06746 1/20 0.35
PKM P14618 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
SCN1A P35498 2/20 0.33
SCN2A Q99250 2/20 0.33
SCN3A Q9NY46 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8350478 1.00 DHODH (0.37) DHODHMEN1KMT2AATMLMNA
SCHEMBL8351806 0.87 L3MBTL1 (0.37) DHODHMEN1KMT2ALMNATP53
SCHEMBL5725047 0.73 ENPP3 (0.34) DHODHPOLBALDH1A1HTT
SCHEMBL5724638 0.65 HTR2A (0.35) MEN1KMT2AALDH1A1
SCHEMBL28875175 0.61 TDP1 (0.68) KMT2ALMNATP53ALDH1A1CYP1A2
SCHEMBL51601 0.61 TDP1 (0.68) KMT2ALMNATP53ALDH1A1CYP1A2
SCHEMBL4570322 0.60 TDP1 (0.57) KMT2ALMNAMAPTPKMALDH1A1
Ethylene Glycol SCHEMBL15661698 0.60 ALDH1A1 (0.62) KMT2ALMNAALDH1A1CYP1A2
SCHEMBL31719483 0.59 TDP1 (0.52) MEN1KMT2AATMLMNACHRNB2
SCHEMBL27773058 0.58 TDP1 (0.50) MEN1KMT2AATMLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174909-B1 FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE H. LUNDBECK A/S (DK) 2001-01-16 US disclosed
US-5998613-A PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS H. LUNDBECK A/S (DK) 1999-12-07 US disclosed
EP-0812318-A1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS H. LUNDBECK A/S (DK) 1997-12-17 EP disclosed
WO-1996026929-A1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS H. LUNDBECK A/S (DK) 1996-09-06 WO disclosed