Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649146 | 1.00 | RAB9A (1.00) | RAB9ANPC1L3MBTL1MAPTMAPK1 | |
| SCHEMBL1753283 | 0.92 | RAB9A (0.85) | RAB9ANPC1L3MBTL1MAPTMAPK1 | |
| SCHEMBL1642242 | 0.90 | NPC1 (0.81) | RAB9ANPC1L3MBTL1MAPTMEN1 | |
| Parachlorophenol SCHEMBL28159625 | 0.87 | L3MBTL1 (0.80) | RAB9ANPC1L3MBTL1MAPTMAPK1 | |
| SCHEMBL1393818 | 0.85 | L3MBTL1 (0.76) | RAB9ANPC1L3MBTL1MAPTMAPK1 | |
| SCHEMBL12835116 | 0.84 | RAB9A (0.72) | RAB9ANPC1L3MBTL1MAPTMEN1 | |
| SCHEMBL28167868 | 0.83 | L3MBTL1 (0.73) | RAB9ANPC1L3MBTL1MAPTMAPK1 | |
| SCHEMBL6202445 | 0.83 | RAB9A (0.71) | RAB9ANPC1L3MBTL1MAPTMEN1 | |
| SCHEMBL6199337 | 0.83 | RAB9A (1.00) | RAB9ANPC1L3MBTL1MAPTMEN1 | |
| SCHEMBL13256390 | 0.83 | RAB9A (0.71) | RAB9ANPC1L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1705169-A2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | Hormos Medical Ltd. (FI) | 2006-09-27 | — | — | EP | disclosed |
| EP-1235776-B1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | HORMOS MEDICAL CORP (FI) | 2006-02-08 | — | — | EP | disclosed |
| US-6875775-B2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD (FI) | 2005-04-05 | — | — | US | disclosed |
| US-20030225130-A1 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD. | 2003-12-04 | — | — | US | disclosed |
| US-6576645-B1 | Such as 3-(4-chloro-1-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)--2-phenylbut-1 -enyl)phenol; producing tissue specific estro-genic and/or antiestrogenic effect | HORMOS MEDICAL OY LTD (FI) | 2003-06-10 | — | — | US | disclosed |
| EP-1235776-A1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Hormos Medical Corporation (FI) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001036360-A1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | HORMOS MEDICAL CORPORATION (FI) | 2001-05-25 | — | — | WO | disclosed |
| US-4464386-A | Insecticidal 3-difluoromethoxyphenyl-1-phenylcarbamoyl-2-pyrazolines | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| US-4410732-A | INSECTICIDES | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4407813-A | Insecticidal pyrazoline derivatives and composition | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1983-10-04 | — | — | US | disclosed |
| US-4038415-A | ENZYME INHIBITORS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1977-07-26 | — | — | US | disclosed |
| US-4016223-A | Prostaglandin dehydrogenase inhibiting agents | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1977-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225130-A1 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | ESR2, ESR1, GPER1 | RAB9A 4327/4885NPC1 1166/4885L3MBTL1 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.