Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275406 | 0.81 | HSD17B1 (0.38) | CYP1A2 | |
| SCHEMBL5872023 | 0.69 | NQO2 (0.30) | — | |
| SCHEMBL4381961 | 0.69 | AOC3 (0.32) | — | |
| SCHEMBL11390274 | 0.68 | ABCG2 (0.50) | CYP1A2CYP1B1HTR1AABCG2CYP1A1 | |
| SCHEMBL8212957 | 0.68 | ABCG2 (0.40) | CYP1A2CYP1B1HTR1AABCG2CYP1A1 | |
| SCHEMBL13346867 | 0.67 | ESR2 (0.40) | CYP1A2CYP1B1HTR1AHTR7HTR2B | |
| SCHEMBL4556560 | 0.67 | BACE1 (0.45) | CYP1A2CYP1B1 | |
| SCHEMBL5871520 | 0.66 | — | — | |
| SCHEMBL7266344 | 0.63 | CYP3A4 (0.40) | CYP1A2 | |
| SCHEMBL14302835 | 0.63 | CYP1A2 (0.51) | CYP1A2CYP1B1HTR1AABCG2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821665-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1998-02-04 | — | — | EP | claimed |
| WO-1996033159-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | claimed |
| EP-1278520-B1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2006-03-01 | — | — | EP | disclosed |
| EP-1278520-A4 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO INC (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6528531-B1 | Coccidiosis in poultry; | MERCK & CO., INC. | 2003-03-04 | — | — | US | disclosed |
| EP-1278520-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | Merck & Co., Inc. (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6432980-B1 | PREVENTION OF COCCIDIOSIS IN POULTRY | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| US-6291480-B1 | CONTROL OF COCCIDIOSIS IN POULTRY. | MERCK & CO., INC. | 2001-09-18 | — | — | US | disclosed |
| WO-2001034150-A1 | ALIPHATIC AMINE SUBSTITUTED PIPERIDYL DIARYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO., INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2001034149-A1 | DIARYL PIPERIDYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO., INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2001034632-A2 | ALIPHATIC HYDROXY SUBSTITUTED PIPERIDYL DIARYL PYRROLE DERIVATIVES AS ANTIPROTOZOAL AGENTS | MERCK & CO., INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4289526-A | FUNGICIDES, HERBICIDES, BACTERICIDES, PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-09-15 | — | — | US | disclosed |
| US-4277469-A | FUNGICIDES, PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-07-07 | — | — | US | disclosed |
| EP-0023756-A2 | Triazol and imidazol derivatives; processes for their preparation, pesticidal compositions containing them and their use; preparation of intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-02-11 | — | — | EP | disclosed |
| US-4217129-A | Fungicidal and herbicidal triazole ketones | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-08-12 | — | — | US | disclosed |
| EP-0009298-A1 | Heterocyclic compounds, processes for their preparation, pesticidal compositions containing them and methods of combating pests | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-04-02 | — | — | EP | disclosed |
| EP-0007707-A1 | 1,3-Diazol- and 1,2,4-triazol-derivatives, processes for their preparation, pesticidal compositions containing them and methods of combating pests | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-02-06 | — | — | EP | disclosed |