Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | VPS4B | O75351 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726294 | 1.00 | SCN5A (0.38) | SCN5AVPS4BVCPALDH1A1CYP2C9 | |
| SCHEMBL5724914 | 0.83 | SCN5A (0.35) | SCN5AVPS4BVCPCYP2C9EPHX2 | |
| SCHEMBL5725809 | 0.80 | DHODH (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5725511 | 0.78 | TBXA2R (0.33) | SCN5A | |
| SCHEMBL5725514 | 0.78 | TBXA2R (0.33) | SCN5A | |
| SCHEMBL8790520 | 0.78 | TBXA2R (0.33) | SCN5A | |
| SCHEMBL30674409 | 0.77 | SCN5A (0.38) | SCN5AVPS4BVCPALDH1A1CYP2C9 | |
| SCHEMBL5724732 | 0.77 | DHODH (0.34) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5726307 | 0.76 | GRIN2B (0.44) | ALDH1A1EPHX2 | |
| Bromide SCHEMBL5725876 | 0.76 | LMNA (0.36) | ALDH1A1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812318-B1 | 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2006-02-08 | — | — | EP | disclosed |
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |