Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725812 | 1.00 | DHODH (0.35) | DHODHSCD5NPC1ALDH1A1LMNA | |
| SCHEMBL5724732 | 0.97 | DHODH (0.34) | DHODHSCD5NPC1ALDH1A1LMNA | |
| SCHEMBL5724892 | 0.86 | HTR2A (0.36) | DHODHSCD5NPC1ALDH1A1LMNA | |
| SCHEMBL5726347 | 0.85 | CHRM2 (0.32) | DHODHNPC1LMNASMN1; SMN2GAA | |
| SCHEMBL5726344 | 0.85 | CHRM2 (0.32) | DHODHNPC1LMNASMN1; SMN2GAA | |
| SCHEMBL5725224 | 0.83 | CHRM2 (0.32) | NPC1LMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL5725148 | 0.80 | SOS1 (0.40) | DHODHSCD5NPC1ALDH1A1LMNA | |
| SCHEMBL5726290 | 0.80 | SCN5A (0.38) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5724740 | 0.79 | SLC6A1 (0.36) | DHODHNPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL5724739 | 0.79 | KDM4E (0.34) | NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812318-B1 | 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2006-02-08 | — | — | EP | disclosed |
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |