SCHEMBL5725795

SCHEMBL5725795

CCOc1noc2c1C(NCCCC=C(c1ccccc1C)c1ccccc1C)CCC2

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A1 P30531 7/20 0.34
CHRM1 P11229 4/20 0.33
CHRM2 P08172 2/20 0.31
CHRM5 P08912 2/20 0.31
CHRM4 P08173 1/20 0.31
CHRM3 P20309 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
DHODH Q02127 2/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
ALOX12 P18054 1/20 0.31
CYP2C19 P33261 1/20 0.31
DRD2 P14416 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5724740 0.87 SLC6A1 (0.36) SLC6A1MEN1KMT2ADHODH
SCHEMBL5726344 0.81 CHRM2 (0.32) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL5726347 0.81 CHRM2 (0.32) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL5725224 0.81 CHRM2 (0.32) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL5725797 0.80 SLC6A1 (0.34) SLC6A1CHRM1CHRM2CHRM5CHRM4
SCHEMBL5724638 0.78 HTR2A (0.35) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL7977242 0.76 SOS1 (0.37) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL7976983 0.75 KDM4E (0.45) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL5724854 0.74 CYP3A4 (0.44) CHRM1CHRM2CHRM5CHRM4CHRM3
SCHEMBL5724677 0.73 SIGMAR1 (0.39) SLC6A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812318-B1 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS LUNDBECK & CO AS H (DK) 2006-02-08 EP disclosed
US-6174909-B1 FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE H. LUNDBECK A/S (DK) 2001-01-16 US disclosed
US-5998613-A PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS H. LUNDBECK A/S (DK) 1999-12-07 US disclosed