Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900021 | 0.86 | ALDH1A1 (0.59) | HTTERCC1ERCC4ALDH1A1P2RX7 | |
| SCHEMBL1873656 | 0.84 | HTT (0.54) | HTTTRPV1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16870958 | 0.81 | L3MBTL1 (0.48) | HTTTRPV1L3MBTL1SMN1; SMN2ERCC1 | |
| SCHEMBL18887690 | 0.78 | ERCC1 (0.50) | TRPV1SMN1; SMN2ERCC1ERCC4ALDH1A1 | |
| SCHEMBL6649593 | 0.78 | HTT (0.69) | HTTTRPV1SMN1; SMN2ERCC1ERCC4 | |
| SCHEMBL17372538 | 0.75 | ALDH1A1 (0.61) | ERCC1ERCC4ALDH1A1P2RX7MAPT | |
| SCHEMBL29337714 | 0.75 | HTT (0.47) | HTTTRPV1CYP3A4CYP2C19ERCC1 | |
| SCHEMBL4709927 | 0.74 | P2RX7 (0.48) | ERCC1ERCC4P2RX7 | |
| SCHEMBL1607208 | 0.74 | HSD17B10 (0.52) | HTTCYP3A4SMN1; SMN2TP53MAPT | |
| SCHEMBL12992173 | 0.74 | CYP3A4 (0.68) | TRPV1L3MBTL1CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |