Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565680 | 0.83 | TYR (0.50) | HSD17B10TTRTYRESR1ESR2 | |
| SCHEMBL365736 | 0.82 | HSD17B10 (0.52) | HSD17B10TTRTYRESR1ESR2 | |
| SCHEMBL4208352 | 0.81 | TYR (0.58) | HSD17B10TTRTYRESR1ESR2 | |
| SCHEMBL6166403 | 0.81 | HSD17B10 (0.56) | HSD17B10TTRTYRBACE1ESR1 | |
| SCHEMBL3794781 | 0.81 | MAPT (0.54) | HSD17B10ESR1ESR2MAPTMEN1 | |
| SCHEMBL28065665 | 0.79 | HSD17B10 (0.45) | HSD17B10TTRBACE1CYP3A4 | |
| SCHEMBL11655822 | 0.79 | TYR (0.67) | HSD17B10TYRESR1ESR2MAPT | |
| SCHEMBL696223 | 0.79 | HSD17B10 (0.54) | HSD17B10TTRTYRBACE1ESR1 | |
| SCHEMBL11329428 | 0.79 | HSD17B10 (0.54) | HSD17B10TTRTYRBACE1ESR1 | |
| SCHEMBL13318422 | 0.78 | HSD17B10 (0.48) | HSD17B10TTRTYRESR1HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 535 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249758-A | Isosorbide-containing polycarbonates and their preparation | SABIC INNOVATIVE PLASTICS IP | 2013-08-14 | — | — | CN | claimed |
| CN-1938379-B | Impact-modified compositions and methods | GEN ELECTRIC | 2012-05-16 | — | — | CN | claimed |
| CN-1976995-B | Polyarylate compositions | GEN ELECTRIC | 2010-06-09 | — | — | CN | claimed |
| US-20100130784-A1 | SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROPAN-2-OL COMPOUNDS | PFIZER INC. | 2010-05-27 | — | — | US | claimed |
| CN-100572349-C | Method for purifying 1, 1-bis (4 '-hydroxy-3' -methylphenyl) cyclohexane and method for producing polycarbonate therefrom | GEN ELECTRIC (NL) | 2009-12-23 | — | — | CN | claimed |
| CN-100554332-C | The goods that polycarbonate molding compositions and specious degree thereof improve | GEN ELECTRIC (NL) | 2009-10-28 | — | — | CN | claimed |
| CN-100535029-C | Method for producing copolyestercarbonates | GEN ELECTRIC (NL) | 2009-09-02 | — | — | CN | claimed |
| CN-101374908-A | Foamed and foamable high glass transition temperature polymers | GEN ELECTRIC (US) | 2009-02-25 | — | — | CN | claimed |
| CN-101370873-A | Annular or tubular shaped articles of novel polymer blends | GEN ELECTRIC (US) | 2009-02-18 | — | — | CN | claimed |
| CN-101370872-A | Food service articles of manufacture comprising high temperature polymers | GEN ELECTRIC (US) | 2009-02-18 | — | — | CN | claimed |
| US-6451830-B1 | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. | 2002-09-17 | — | — | US | claimed |
| US-6448295-B1 | TREATING CARDIOVASCULAR DISEASE; ATHEROSCLEROSIS, DYSLIPIDEMA HYPERCHOLESTEROLAEMIA; DECREASING CONCENTRATIONS OF LOW DENSITY LIPOPROTEIN AND RAISING LEVEL OF HIGH DENSITY LIPOPROTEIN | G.D. SEARLE & CO. | 2002-09-10 | — | — | US | claimed |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | SIKORSKI JAMES A (US) | 2002-08-29 | — | — | US | claimed |
| US-20010018446-A1 | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. (US) | 2001-08-30 | — | — | US | claimed |
| EP-1115695-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| EP-1115693-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| EP-1115694-A1 | SUBSTITUTED N-ALIPHATIC-N-AROMATIC (TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| WO-2000018723-A1 | SUBSTITUTED N-ALIPHATIC-N-AROMATIC TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
| WO-2000018724-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(n+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
| WO-2000018721-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018446-A1 | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity | CETP, DBI, MTTP | HSD17B10 422/4885TTR 248/4885TYR 2475/4885 |
| US-20100130784-A1 | SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROPAN-2-OL COMPOUNDS | APOB, LDLR, HDLBP | HSD17B10 941/4885TTR 41/4885TYR 1266/4885 |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | CETP, PCTP, DBI | HSD17B10 1281/4885TTR 1355/4885TYR 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.