Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726072 | 0.87 | TGFBR1 (0.48) | MAPK14MAPK8MAPK10MAPK9TGFBR1 | |
| SCHEMBL14519501 | 0.80 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL14519513 | 0.79 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL6070210 | 0.77 | TGFBR1 (0.56) | MAPK14TGFBR1PRKACAGSK3BRPS6KA3 | |
| SCHEMBL14519502 | 0.76 | CDK4 (0.57) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL14519474 | 0.73 | TGFBR1 (0.70) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL14519519 | 0.73 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL14519530 | 0.73 | MAPK8 (0.53) | MAPK14MAPK13MAPK12MAPK11MAPK8 | |
| SCHEMBL14519509 | 0.72 | MAPK8 (0.79) | MAPK14MAPK13MAPK12MAPK8MAPK10 | |
| SCHEMBL4602908 | 0.71 | BRAF (0.56) | MAPK14MAPK13MAPK12MAPK11TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455579-B1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | SYNGENTA CROP PROTECTION, INC. | 2005-04-14 | — | — | US | disclosed |
| EP-1455579-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | Syngenta Participations AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049542-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | DHFR, CYP3A7, CBR3 | MAPK14 3517/4885MAPK13 3511/4885MAPK12 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.