Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070210 | 0.90 | TGFBR1 (0.56) | TGFBR1MAPK14RPS6KA3AKT1AURKA | |
| SCHEMBL5726693 | 0.87 | MAPK14 (0.50) | TGFBR1MAPK14RPS6KA3PRKACAGSK3B | |
| SCHEMBL27997668 | 0.80 | AURKA (0.50) | RPS6KA3AURKAFGFR1PRKACAPRKCD | |
| SCHEMBL6132086 | 0.78 | TGFBR1 (0.50) | TGFBR1MAPK14RPS6KA3AKT1AURKA | |
| SCHEMBL6070023 | 0.72 | TGFBR1 (0.32) | TGFBR1MAPK14PRKCDMAPK10 | |
| SCHEMBL27618478 | 0.71 | MAPK8 (0.52) | AKT1AURKAPIM1MAPK8KCNH2 | |
| SCHEMBL6070097 | 0.69 | TGFBR1 (0.60) | TGFBR1MAPK14RPS6KA3AKT1AURKA | |
| SCHEMBL5248907 | 0.69 | RPS6KA3 (0.81) | TGFBR1MAPK14RPS6KA3AKT1AURKA | |
| Bromide SCHEMBL11756541 | 0.68 | RPS6KA3 (0.79) | TGFBR1MAPK14RPS6KA3AKT1AURKA | |
| SCHEMBL18391615 | 0.67 | MAPK8 (0.56) | CDK2GSK3BMAPK8MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455579-B1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | SYNGENTA CROP PROTECTION, INC. | 2005-04-14 | — | — | US | disclosed |
| EP-1455579-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | Syngenta Participations AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049542-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | DHFR, CYP3A7, CBR3 | TGFBR1 2150/4885MAPK14 3517/4885RPS6KA3 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.