Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727482 | 0.92 | TDP2 (0.32) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5728721 | 0.89 | TDP2 (0.40) | NPSR1TDP2PTGESPTGS1PTGS2 | |
| SCHEMBL5726664 | 0.87 | KDM4E (0.32) | KDM4ENPSR1TDP2PTGS2 | |
| SCHEMBL6074135 | 0.86 | TDP2 (0.31) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5727753 | 0.86 | ALDH1A1 (0.32) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5727234 | 0.86 | TDP2 (0.41) | TDP2PTGESPTGS1PTGS2SCN5A | |
| SCHEMBL5726801 | 0.85 | TDP2 (0.32) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5726775 | 0.85 | KDM4E (0.32) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5728380 | 0.83 | KDM4E (0.32) | KDM4ENPSR1TDP2PTGESPTGS1 | |
| SCHEMBL5727151 | 0.83 | TDP2 (0.39) | KDM4ETDP2PTGESPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425278-B1 | INSECTICIDAL 3-(2,6-DISUBSTITUTED PHENYL)-5- 4- OR 5-ARYLTHIEN-2- OR -3-YL|-1,2,4-TRIAZOLES | DOW AGROSCIENCES LLC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-7056940-B2 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-2-yl]-1,2,4-triazoles | DOW AGROSCIENCES LLC (US) | 2006-06-06 | — | — | US | disclosed |
| US-6949576-B2 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-3-yl]-1,2,4-triazoles | DOW AGROSCIENCES LLC (US) | 2005-09-27 | — | — | US | disclosed |
| US-20040171661-A1 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-2-yl]-1,2,4-triazoles | HEGDE VIDYADHAR BABU (US) | 2004-09-02 | — | — | US | disclosed |
| US-6770665-B2 | TRIAZOLE COMPOUNDS HAVING A 2,6-DISUBSTITUTED-PHENYL GROUP IN THE 3-POSITION, ARYLTHIEN-2- OR -3-YL IN THE 5-POSITION AND AN ALKYL GROUP IN THE 1-POSITION ARE EFFECTIVE IN CONTROLLING LEPIDOPTERA, COLEOPTERA, MITES AND OTHER SUCKING PESTS. | DOW AGROSCIENCES LLC | 2004-08-03 | — | — | US | disclosed |
| US-20040072887-A1 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-3-yl]-1,2,4-triazoles | HEGDE VIDYADHAR BABU (US) | 2004-04-15 | — | — | US | disclosed |
| US-20030134748-A1 | Insecticial 3-(2,6-disubstituted phenyl)-5-[4- or 5-arylthien-2- or -3-yl]-1,2,4-triazoles | DOW AGROSCIENCES LLC | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171661-A1 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-2-yl]-1,2,4-triazoles | L3MBTL3, API5, L3MBTL4 | KDM4E 119/4885NPSR1 3310/4885TDP2 2312/4885 |
| US-20040072887-A1 | Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-3-yl]-1,2,4-triazoles | L3MBTL3, API5, L3MBTL4 | KDM4E 135/4885NPSR1 3270/4885TDP2 2641/4885 |
| US-20030134748-A1 | Insecticial 3-(2,6-disubstituted phenyl)-5-[4- or 5-arylthien-2- or -3-yl]-1,2,4-triazoles | L3MBTL3, API5, L3MBTL4 | KDM4E 239/4885NPSR1 3160/4885TDP2 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.