Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.73 |
| ▸ | DRD4 | P21917 | 13/20 | 0.73 |
| ▸ | DRD3 | P35462 | 13/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045568 | 0.72 | NFKB1 (0.68) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL6864588 | 0.69 | DRD2 (0.70) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8312005 | 0.67 | DRD2 (1.00) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8864198 | 0.67 | DRD2 (0.72) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8864160 | 0.67 | DRD2 (0.72) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL5640879 | 0.67 | DRD2 (0.72) | DRD2DRD4DRD3NFKB1NFKB2 | |
| Bromide SCHEMBL6281511 | 0.66 | DRD2 (0.70) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL7116091 | 0.65 | NFKB1 (0.57) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL7116097 | 0.65 | NFKB1 (0.57) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8844842 | 0.64 | DRD2 (1.00) | DRD2DRD4DRD3DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421086-B1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH CORP (US) | 2006-08-30 | — | — | EP | claimed |
| EP-1421086-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | Wyeth (US) | 2004-05-26 | — | — | EP | claimed |
| US-6541502-B1 | Treatment of disorders associated with dopamine dysregulation such as schizophrenia | WYETH | 2003-04-01 | — | — | US | claimed |
| WO-2003008419-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH (US) | 2003-01-30 | — | — | WO | claimed |
| EP-1421086-B1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH CORP (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1421086-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | Wyeth (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6541502-B1 | Treatment of disorders associated with dopamine dysregulation such as schizophrenia | WYETH | 2003-04-01 | — | — | US | disclosed |
| WO-2003008419-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH (US) | 2003-01-30 | — | — | WO | disclosed |