Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 1.00 |
| ▸ | DRD4 | P21917 | 15/20 | 1.00 |
| ▸ | DRD3 | P35462 | 15/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314007 | 0.90 | DRD2 (0.81) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8314369 | 0.90 | DRD2 (0.81) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8312627 | 0.90 | DRD2 (0.81) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8313970 | 0.87 | DRD2 (0.77) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8314765 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3NFKB1NFKB2 | |
| Aplindore SCHEMBL3192098 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3 | |
| Aplindore SCHEMBL29359212 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3 | |
| Aplindore SCHEMBL119499 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3 | |
| SCHEMBL8045568 | 0.79 | NFKB1 (0.68) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8317510 | 0.78 | DRD2 (0.64) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| JP-9169764-A | — | — | None | — | — | JP | disclosed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750556-A | REDUCING DOPAMINE SYNTHESIS AND RELEASE, SCHIZOPHRENIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| JP-H09169764-A | 2-(AMINOMETHYL)-3,4,7,9-TETRAHYDRO-2H-PYRANO(2,3-E) INDOL-8-ONE AND DERIVATIVE OF THE SAME | AMERICAN HOME PROD CORP | 1997-06-30 | — | — | JP | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |