Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.66 |
| ▸ | DRD3 | P35462 | 7/20 | 0.66 |
| ▸ | DRD2 | P14416 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729865 | 0.80 | DRD2 (0.57) | DRD4DRD3DRD2KDM4EHPGD | |
| SCHEMBL5729832 | 0.78 | DRD2 (0.54) | DRD4DRD3DRD2KDM4EHPGD | |
| SCHEMBL6864820 | 0.69 | DRD4 (0.45) | DRD4DRD3DRD2KDM4EHPGD | |
| SCHEMBL5730420 | 0.69 | DRD2 (0.63) | DRD4DRD3DRD2NFKB1NFKB2 | |
| SCHEMBL6749348 | 0.65 | NFKB1 (0.62) | NFKB1NFKB2RELA | |
| SCHEMBL5729792 | 0.64 | NFKB1 (0.34) | DRD4DRD3DRD2NFKB1NFKB2 | |
| SCHEMBL5729167 | 0.63 | DRD2 (0.73) | DRD4DRD3DRD2NFKB1NFKB2 | |
| SCHEMBL7110632 | 0.62 | CHRM3 (0.40) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL7110625 | 0.62 | CHRM3 (0.40) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL6864825 | 0.62 | DRD2 (0.41) | DRD4DRD3DRD2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409490-B1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA A|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH CORP (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1421086-B1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH CORP (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1421086-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | Wyeth (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-1409490-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA A]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | Wyeth (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6541501-B2 | Dopamine autoreceptor agonists | WYETH | 2003-04-01 | — | — | US | disclosed |
| US-6541502-B1 | Treatment of disorders associated with dopamine dysregulation such as schizophrenia | WYETH | 2003-04-01 | — | — | US | disclosed |
| US-20030037701-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH | 2003-02-27 | — | — | US | disclosed |
| WO-2003008420-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[A]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003008419-A1 | 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY | WYETH (US) | 2003-01-30 | — | — | WO | disclosed |