Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ILK | Q13418 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402669 | 0.87 | DRD1 (0.47) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL14491026 | 0.85 | ALDH1A1 (0.42) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL1868350 | 0.84 | HSP90AA1 (0.48) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL14350130 | 0.84 | GAA (0.45) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL13516427 | 0.80 | MAPT (0.50) | ALDH1A1MAPK1GAAGFERKDM4E | |
| SCHEMBL5730709 | 0.76 | GAA (0.39) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL4863136 | 0.76 | KDM4E (0.64) | ALDH1A1MAPK1GAAKDM4EMEN1 | |
| SCHEMBL13310497 | 0.75 | CCNT1 (0.42) | ALDH1A1MAPK1GAAHTTGFER | |
| SCHEMBL686489 | 0.74 | ILK (0.72) | ILK | |
| SCHEMBL14502125 | 0.74 | ALDH1A1 (0.33) | ALDH1A1MAPK1GAAHTTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070129382-A1 | Crf receptor antagonists, their preparations, their pharmaceutical composition, and their uses | SB PHARMCO PUERTO RICO (PR) | 2007-06-07 | — | — | US | disclosed |
| US-20070129382-A1 | Crf receptor antagonists, their preparations, their pharmaceutical composition, and their uses | SB PHARMCO PUERTO RICO (PR) | 2007-06-07 | — | — | US | disclosed |
| EP-1218381-B1 | AMINO SUBSTITUTED PYRAZOLO¬1,5-a|-1,5-PYRIMIDINES AND PYRAZOLO¬1,5-a|-1,3,5-TRIAZINES | NEUROGEN CORP (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6476038-B1 | Amino substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines | NEUROGEN CORPORATION | 2002-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129382-A1 | Crf receptor antagonists, their preparations, their pharmaceutical composition, and their uses | CRH, CRHR1, CRHR2 | ALDH1A1 2863/4885MAPK1 3347/4885GAA 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.