Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739687 | 0.86 | TP53 (0.53) | ALDH1A1KDM4EMAPTRXFP1NPC1 | |
| SCHEMBL5732186 | 0.85 | MEN1 (0.53) | ALDH1A1KDM4EMAPTNPSR1RXFP1 | |
| SCHEMBL5731508 | 0.85 | NHERF1 (0.54) | ALDH1A1KDM4EMAPTRXFP1BCAT1 | |
| SCHEMBL5750987 | 0.84 | KDM4E (0.57) | ALDH1A1KDM4EMAPTBCAT1NPC1 | |
| SCHEMBL6753662 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTNPSR1RXFP1 | |
| SCHEMBL5740825 | 0.77 | NPC1 (0.53) | ALDH1A1KDM4EMAPTRXFP1BCAT1 | |
| SCHEMBL5731039 | 0.74 | CYP1A2 (0.49) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL7549923 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL13753883 | 0.74 | KDM4E (0.77) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL7551616 | 0.74 | CYP1A2 (0.73) | ALDH1A1KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633709-A1 | ANTI-DIABETIC AGENTS | Pfizer Products Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096768-A1 | ANTI-DIABETIC AGENTS | PFIZER PRODUCTS INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20040220229-A1 | insulin resistance; central nervous system disorders; vision defects; anticholesterol agents;antilipemic agents; antiischemic agents | PFIZER INC | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220229-A1 | insulin resistance; central nervous system disorders; vision defects; anticholesterol agents;antilipemic agents; antiischemic agents | IRS1, INSR, GPR119 | ALDH1A1 1121/4885KDM4E 4572/4885MAPT 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.