Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731587 | 0.83 | HRH3 (0.43) | SMN1; SMN2HRH3TSHRALDH1A1MAPT | |
| SCHEMBL5731478 | 0.80 | KDM4E (0.44) | HRH3ALDH1A1MAPTL3MBTL1IDO1 | |
| SCHEMBL5731045 | 0.74 | L3MBTL1 (0.39) | POLBSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL5730835 | 0.73 | CASP1 (0.36) | HRH3TSHRGFERALDH1A1MEN1 | |
| SCHEMBL5730937 | 0.72 | — | — | |
| SCHEMBL19494347 | 0.71 | POLB (0.43) | POLBSMN1; SMN2TSHRGFERALDH1A1 | |
| SCHEMBL22897383 | 0.71 | HRH3 (0.50) | POLBSMN1; SMN2HRH3ALDH1A1MAPT | |
| SCHEMBL5732544 | 0.69 | ALDH1A1 (0.37) | POLBSMN1; SMN2GFERALDH1A1MAPT | |
| SCHEMBL8296046 | 0.63 | MAPT (0.41) | SMN1; SMN2TSHRALDH1A1MAPTMEN1 | |
| SCHEMBL24519714 | 0.63 | IDO1 (0.50) | POLBALDH1A1MAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |