Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23567825 | 0.95 | L3MBTL1 (0.58) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL16839107 | 0.89 | LMNA (0.57) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL24096077 | 0.88 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL28008974 | 0.85 | HTT (0.59) | SMN1; SMN2LMNAL3MBTL1ALDH1A1TSHR | |
| SCHEMBL26958103 | 0.85 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL16111718 | 0.85 | ALDH1A1 (0.53) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL23568002 | 0.84 | HTT (0.56) | SMN1; SMN2LMNAL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL12516501 | 0.83 | LMNA (0.54) | SMN1; SMN2RAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL28003839 | 0.83 | ALDH1A1 (0.60) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL3231538 | 0.83 | PPID (0.64) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933379-B1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO (JP) | 2006-03-22 | — | — | EP | disclosed |
| CN-1214040-C | Peptide derivatives having thiazolyl-alanine residues | SHIONOGI & CO (JP) | 2005-08-10 | — | — | CN | disclosed |
| US-6319902-B1 | TO ACTIVATE THE CENTRAL NERVOUS SYSTEM, SUCH AS, FOR EXAMPLE, SUSTAINED ACETYLCHOLINE RELEASING ACTION, ANTI-RESERPINE ACTION AND LOCOMOTOR INCREMENT | SHIONOGI & CO., LTD. (JP) | 2001-11-20 | — | — | US | disclosed |
| CN-1235610-A | Peptide derivatives having thiazolyl-alanine residues | SHIONOGI & CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0933379-A1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO., LTD. (JP) | 1999-08-04 | — | — | EP | disclosed |