Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 5/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30518168 | 0.90 | HDAC1 (0.60) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL210559 | 0.74 | HDAC1 (0.82) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL5091711 | 0.72 | MAPK8 (0.55) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL5742820 | 0.71 | HDAC1 (0.65) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL6648686 | 0.70 | CAMKK2 (0.67) | GSK3B | |
| SCHEMBL7464625 | 0.69 | DYRK1A (0.52) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL5094681 | 0.69 | MAPK8 (0.54) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL212828 | 0.69 | PDE4B (0.44) | HDAC1HDAC3 | |
| SCHEMBL27576350 | 0.68 | CAMKK2 (0.55) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL2732829 | 0.67 | HDAC1 (0.85) | HDAC1HDAC3NCOR1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735319-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-12-27 | — | — | EP | claimed |
| WO-2005092899-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2005-10-06 | — | — | WO | claimed |