Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 10/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27488114 | 1.00 | CMA1 (0.41) | CMA1F2PRSS1F10ACE | |
| Hydrochloric Acid SCHEMBL5734716 | 0.86 | DPP4 (0.50) | F2F10ACEACE2DPP4 | |
| SCHEMBL5734046 | 0.85 | TRHR (0.47) | — | |
| SCHEMBL7870420 | 0.81 | F2 (0.46) | F2PRSS1ACESCN9ADPP4 | |
| SCHEMBL27503453 | 0.81 | F2 (0.46) | F2PRSS1ACESCN9ADPP4 | |
| SCHEMBL20787862 | 0.78 | SCN9A (0.47) | CMA1F2PRSS1ACESCN9A | |
| SCHEMBL20787861 | 0.78 | SCN9A (0.47) | CMA1F2PRSS1ACESCN9A | |
| SCHEMBL5735443 | 0.77 | REN (0.43) | F2PRSS1ACESCN9ADPP4 | |
| SCHEMBL5735435 | 0.77 | REN (0.43) | F2PRSS1ACESCN9ADPP4 | |
| SCHEMBL5736095 | 0.76 | ACE (0.51) | CMA1F2PRSS1ACESCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933379-B1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO (JP) | 2006-03-22 | — | — | EP | disclosed |
| CN-1214040-C | Peptide derivatives having thiazolyl-alanine residues | SHIONOGI & CO (JP) | 2005-08-10 | — | — | CN | disclosed |
| US-6319902-B1 | TO ACTIVATE THE CENTRAL NERVOUS SYSTEM, SUCH AS, FOR EXAMPLE, SUSTAINED ACETYLCHOLINE RELEASING ACTION, ANTI-RESERPINE ACTION AND LOCOMOTOR INCREMENT | SHIONOGI & CO., LTD. (JP) | 2001-11-20 | — | — | US | disclosed |
| CN-1235610-A | Peptide derivatives having thiazolyl-alanine residues | SHIONOGI & CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0933379-A1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO., LTD. (JP) | 1999-08-04 | — | — | EP | disclosed |