Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 2/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372863 | 0.81 | F2 (0.59) | GAAMGLLFAAHF2HDAC6 | |
| SCHEMBL5203573 | 0.76 | F2 (0.57) | GAAMGLLF2HDAC6TNKS | |
| SCHEMBL7376188 | 0.74 | GAA (0.53) | GAAMGLLF2HDAC6TNKS | |
| SCHEMBL5733657 | 0.74 | GAA (0.55) | GAAF2TNKSPARP1PARP14 | |
| SCHEMBL7373276 | 0.73 | GAA (0.51) | GAAMGLLF2HDAC6TNKS | |
| SCHEMBL1063457 | 0.72 | MGLL (0.61) | GAAMGLLFAAHHCAR3CA12 | |
| SCHEMBL5372866 | 0.72 | GAA (0.52) | GAAF2HDAC6MEN1KMT2A | |
| SCHEMBL6429862 | 0.71 | GAA (0.60) | GAAF2TNKSPARP1PARP14 | |
| SCHEMBL14523154 | 0.70 | ALDH1A1 (0.45) | GAAMGLLFAAHMEN1KMT2A | |
| SCHEMBL6428994 | 0.70 | GAA (0.70) | GAACA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |