Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.55 |
| ▸ | CCR2 | P41597 | 5/20 | 0.55 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | TACR1 | P25103 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729519 | 0.87 | CCR2 (0.51) | KCNH2CCR2SLC18A3GRIN2BTACR1 | |
| SCHEMBL5729653 | 0.73 | CCR2 (0.52) | KCNH2CCR2SLC18A3GRIN2BTACR1 | |
| SCHEMBL24700396 | 0.71 | NAMPT (0.45) | SLC18A3GRIN2BTACR1KDM4EALDH1A1 | |
| SCHEMBL28266943 | 0.69 | SLC18A3 (0.65) | SLC18A3GRIN2BALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL2965273 | 0.69 | SLC18A3 (0.81) | SLC18A3GRIN2BALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL1867197 | 0.69 | CCR2 (0.54) | CCR2SLC18A3GRIN2BALDH1A1CYP2D6 | |
| SCHEMBL15282873 | 0.69 | CCR2 (0.54) | CCR2SLC18A3GRIN2BALDH1A1CYP2D6 | |
| SCHEMBL1867198 | 0.69 | GRIN2B (0.48) | SLC18A3GRIN2BKDM4EALDH1A1CYP2D6 | |
| SCHEMBL7477011 | 0.69 | SLC18A3 (0.59) | KCNH2SLC18A3GRIN2BKDM4EALDH1A1 | |
| SCHEMBL7986736 | 0.69 | SLC18A3 (0.55) | CCR2SLC18A3GRIN2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318811-B1 | CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1318811-A4 | CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1318811-A1 | CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2003-06-18 | — | — | EP | disclosed |
| US-6545023-B2 | For treating rheumatoid arthritis; for examle, 1-(4-(4-fluorophenyl)piperidin-1-yl),3-(2-methoxy-4 -chlorobenzylaminocarbonyl),3-isopropyl-cyclopentane | MERCK & CO., INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020049222-A1 | Cyclopentyl modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2002-04-25 | — | — | US | disclosed |
| WO-2002013824-A1 | CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2002-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049222-A1 | Cyclopentyl modulators of chemokine receptor activity | CCR1, CCRL2, CCR5 | KCNH2 3123/4885CCR2 6/4885SLC18A3 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.