Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 16/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 16/20 | 0.79 |
| ▸ | MAPT | P10636 | 15/20 | 0.79 |
| ▸ | POLB | P06746 | 11/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.79 |
| ▸ | RECQL | P46063 | 14/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.55 |
| ▸ | MITF | O75030 | 8/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.55 |
| ▸ | GFER | P55789 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | XBP1 | P17861 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736031 | 1.00 | MEN1 (0.79) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL5734258 | 0.85 | ABL1 (0.64) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL5734261 | 0.85 | ABL1 (0.64) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL3755954 | 0.73 | ITGA4 (0.65) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL3755958 | 0.73 | ITGA4 (0.65) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL3757779 | 0.73 | NR4A1 (0.64) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL3757780 | 0.73 | NR4A1 (0.64) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL5735689 | 0.72 | NR4A1 (0.63) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL5735693 | 0.72 | NR4A1 (0.63) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL5737024 | 0.69 | ABL1 (1.00) | MEN1KMT2APOLBGAAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399156-B1 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS (AN) | 2006-11-22 | — | — | EP | claimed |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | LABORATOIRES SERONO SA (CH) | 2004-11-04 | — | — | US | claimed |
| EP-1399156-B1 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS (AN) | 2006-11-22 | — | — | EP | disclosed |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | LABORATOIRES SERONO SA (CH) | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | G6PC1, PPM1D, PTPRS | MEN1 3799/4885KMT2A 4359/4885MAPT 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.