Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 13/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1956889 | 0.93 | KDM4E (0.60) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4733055 | 0.91 | KDM4E (0.55) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL382822 | 0.90 | KDM4E (0.66) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8008956 | 0.89 | POLB (0.54) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL383820 | 0.88 | ALDH1A1 (0.66) | KDM4ESMN1; SMN2AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL9173937 | 0.87 | SMN1; SMN2 (0.56) | KDM4ESMN1; SMN2AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL8541373 | 0.87 | POLB (0.57) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| Benzene SCHEMBL29227606 | 0.86 | ALDH1A1 (0.63) | KDM4ECYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL8008958 | 0.86 | POLB (0.55) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11574967 | 0.86 | POLB (0.55) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281726-A1 | Piperidine derivatives for the treatment of chemokine or h1 mediated disease state | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
| EP-1611124-A1 | PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CHEMOKINE OR H1 MEDIATED DISEASE STATE | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004085423-A1 | PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CHEMOKINE OR H1 MEDIATED DISEASE STATE | ASTRAZENECA AB (SE) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281726-A1 | Piperidine derivatives for the treatment of chemokine or h1 mediated disease state | CCR3, CCR1, CCL11 | KDM4E 2830/4885CYP1A2 2063/4885CYP2D6 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.