Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 13/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 13/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 13/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 13/20 | 0.52 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.52 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737050 | 0.92 | ABCC9 (0.61) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737462 | 0.88 | ABCC9 (0.56) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5736719 | 0.88 | ALDH1A1 (0.50) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737469 | 0.88 | PDK1 (0.58) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737589 | 0.88 | PDK1 (0.68) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5738883 | 0.85 | ABCC9 (0.57) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5738363 | 0.84 | PDK1 (0.56) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737269 | 0.83 | PDK1 (0.68) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5738526 | 0.83 | PDK1 (0.58) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL6571184 | 0.82 | ABCC9 (0.60) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |