Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 12/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 12/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 12/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 12/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735151 | 0.90 | ALDH1A1 (0.50) | ALDH1A1MAPK1MEN1KMT2APDK1 | |
| SCHEMBL5737050 | 0.89 | ABCC9 (0.61) | MEN1KMT2APDK1PDK2PDK3 | |
| SCHEMBL5737696 | 0.89 | L3MBTL1 (0.55) | ALDH1A1MEN1KMT2APDK1PDK2 | |
| SCHEMBL5739340 | 0.89 | PDK1 (0.64) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5736812 | 0.88 | PDK1 (0.52) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL27533431 | 0.87 | ABCC9 (0.56) | MEN1KMT2APDK1PDK2PDK3 | |
| SCHEMBL27533429 | 0.87 | ABCC9 (0.56) | MEN1KMT2APDK1PDK2PDK3 | |
| SCHEMBL5737469 | 0.85 | PDK1 (0.58) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5735640 | 0.83 | PTGES2 (0.59) | ALDH1A1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5738883 | 0.82 | ABCC9 (0.57) | ALDH1A1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |