Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573598 | 0.84 | QPCT (0.41) | QPCTALDH1A1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL574202 | 0.83 | LMNA (0.36) | ALDH1A1LMNAMAPTEHMT2 | |
| SCHEMBL4439400 | 0.82 | POLB (0.40) | ALDH1A1LMNAMAPTMAPK1KDM4E | |
| SCHEMBL2578935 | 0.81 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL4436014 | 0.80 | TACR1 (0.38) | MAPTSLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL4434425 | 0.79 | KDM4E (0.39) | ALDH1A1LMNASLC6A4SLC6A2TACR1 | |
| SCHEMBL573664 | 0.78 | SMN1; SMN2 (0.42) | QPCTALDH1A1LMNACHEK1SIRT6 | |
| SCHEMBL4438391 | 0.78 | KMT2A (0.36) | ALDH1A1LMNAMAPTSLC6A4SLC6A2 | |
| SCHEMBL4433895 | 0.77 | KDM4E (0.39) | ALDH1A1LMNASLC6A4SLC6A2TACR1 | |
| SCHEMBL4444516 | 0.76 | MAPK1 (0.40) | ALDH1A1LMNAMAPTSLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |