Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574274 | 0.84 | EHMT2 (0.39) | KMT2AEHMT2MEN1 | |
| SCHEMBL573693 | 0.83 | QPCT (0.39) | LMNAEHMT2ALDH1A1MAPT | |
| SCHEMBL4439400 | 0.81 | POLB (0.40) | LMNAKMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4433895 | 0.81 | KDM4E (0.39) | LMNAKMT2AALDH1A1GAAMEN1 | |
| SCHEMBL4434425 | 0.81 | KDM4E (0.39) | LMNAKMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL4438391 | 0.79 | KMT2A (0.36) | LMNAKMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4436014 | 0.78 | TACR1 (0.38) | KMT2AMEN1MAPT | |
| SCHEMBL4444516 | 0.78 | MAPK1 (0.40) | LMNAKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4434450 | 0.78 | TACR1 (0.38) | KMT2AALDH1A1HTTL3MBTL1MEN1 | |
| SCHEMBL4437504 | 0.77 | MAPT (0.45) | LMNAKMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |