Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434450 | 0.92 | TACR1 (0.38) | TACR1SLC6A4SLC6A2SLC6A3MAPT | |
| SCHEMBL4434425 | 0.88 | KDM4E (0.39) | TACR1SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL4438391 | 0.85 | KMT2A (0.36) | SLC6A4SLC6A2SNCATDP1SLC6A3 | |
| SCHEMBL4437504 | 0.82 | MAPT (0.45) | TACR1TDP1MAPTMEN1KMT2A | |
| SCHEMBL4433895 | 0.82 | KDM4E (0.39) | TACR1SLC6A4SLC6A2MEN1KMT2A | |
| SCHEMBL4444516 | 0.81 | MAPK1 (0.40) | TACR1SLC6A4SLC6A2SLC6A3MAPT | |
| SCHEMBL573693 | 0.80 | QPCT (0.39) | TACR1SLC6A4SLC6A2TDP1SLC6A3 | |
| SCHEMBL4439400 | 0.80 | POLB (0.40) | MAPTMEN1KMT2A | |
| SCHEMBL4437157 | 0.80 | HCAR3 (0.39) | MAPTMEN1KMT2A | |
| SCHEMBL4436886 | 0.80 | SLC6A2 (0.35) | TACR1SLC6A4SLC6A2SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |