Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 1/20 | 0.39 |
| ▸ | ATP4B | P51164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964155 | 0.86 | CHEK1 (0.58) | CHEK1DDAH1GAAL3MBTL1MEN1 | |
| SCHEMBL6994637 | 0.85 | CHEK1 (0.56) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL5736933 | 0.84 | CHEK1 (0.55) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL3938941 | 0.82 | CHEK1 (0.57) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL7485025 | 0.81 | CHEK1 (0.57) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL7479051 | 0.81 | CHEK1 (0.53) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL6999051 | 0.80 | CHEK1 (0.56) | CHEK1GAAL3MBTL1MEN1POLB | |
| SCHEMBL4919548 | 0.80 | DDAH1 (0.55) | DDAH1GAATDP1ALDH1A1 | |
| SCHEMBL2899660 | 0.80 | DDAH1 (0.55) | CHEK1DDAH1GAAL3MBTL1MAPT | |
| SCHEMBL30518181 | 0.80 | DDAH1 (0.55) | DDAH1GAATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |