SCHEMBL4270442

SCHEMBL4270442

NCc1nc2c(F)cccc2[nH]1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 1/20 0.42
GAA P10253 2/20 0.40
MGAM O43451 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
CACNA1H O95180 1/20 0.39
PARP1 P09874 1/20 0.38
IDO1 P14902 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
POLB P06746 2/20 0.38
CHEK1 O14757 1/20 0.38
SLC40A1 Q9NP59 4/20 0.37
HTR2A P28223 1/20 0.37
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL23497492 0.98 EGLN1 (0.41) EGLN1GAAMGAMSIMGAM2
Hydrochloric Acid SCHEMBL23782097 0.98 EGLN1 (0.41) EGLN1GAAMGAMSIMGAM2
Hydrochloric Acid SCHEMBL23497490 0.97 EGLN1 (0.40) EGLN1GAAMGAMSIMGAM2
SCHEMBL5744116 0.82 EGLN1 (0.42) EGLN1GAAMGAMSIMGAM2
SCHEMBL17308357 0.82 DDAH1 (0.53) EGLN1GAAMGAMSIMGAM2
SCHEMBL4061481 0.82 MGAM (0.40) EGLN1GAAMGAMSIMGAM2
SCHEMBL7001717 0.80 CHEK1 (0.49) EGLN1GAAMGAMSIMGAM2
SCHEMBL5736933 0.80 CHEK1 (0.55) GAACACNA1HPARP1SMN1; SMN2NPC1
SCHEMBL22075724 0.79 SLC40A1 (0.40) EGLN1GAAMGAMSIMGAM2
Hydrochloric Acid SCHEMBL6999319 0.79 GAA (0.51) EGLN1GAAMGAMSIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026101698-A1 HEPCIDIN MIMETIC COMPOUNDS AND USES THEREOF PROTAGONIST THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-7534793-B2 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity SMITHKLINE BEECHAM P.L.C. (GB) 2009-05-19 US disclosed
EP-1305308-B1 AMINOPIPERIDINE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2006-12-20 EP disclosed
US-20060014749-A1 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity SMITHKLINE BEECHAM P.L.C. 2006-01-19 US disclosed
US-6962917-B2 Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity SMITHKLINE BEECHAM P.L.C. (GB) 2005-11-08 US disclosed
US-20040038998-A1 Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity SMITHKLINE BEECHAM P.L.C. (GB) 2004-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040038998-A1 Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity AZI2, AMPD2, AMPD1 EGLN1 3945/4885GAA 904/4885MGAM 769/4885
US-20060014749-A1 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity AZI2, NPEPPS, AMPD2 EGLN1 3079/4885GAA 1576/4885MGAM 1769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.