Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6405313 | 0.99 | HSD11B1 (0.38) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5739775 | 0.89 | HSD11B1 (0.37) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL6405378 | 0.88 | HSD11B1 (0.37) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5611716 | 0.85 | DRD2 (0.39) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5592512 | 0.85 | DRD2 (0.39) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5592486 | 0.85 | DRD2 (0.39) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL5739570 | 0.84 | DRD2 (0.38) | HSD11B1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5738823 | 0.81 | POLB (0.37) | HSD11B1DRD2DRD3KCNH2BCL2A1 | |
| SCHEMBL5811923 | 0.81 | DGAT1 (0.35) | HSD11B1DRD2DRD3KCNH2CCNK | |
| Hydrochloric Acid SCHEMBL6407510 | 0.81 | POLB (0.36) | HSD11B1DRD2DRD3HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697353-A2 | ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS WITH AFFINITY FOR 5-HT1 RECEPTORS | Pfizer Products Incorporated (US) | 2006-09-06 | — | — | EP | claimed |
| US-20050227980-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | PFIZER INC. | 2005-10-13 | — | — | US | claimed |
| US-20050227981-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | PFIZER INC | 2005-10-13 | — | — | US | claimed |
| WO-2005061491-A2 | ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS WITH AFFINITY FOR 5-HT1 RECEPTORS | PFIZER PRODUCTS INC. (US) | 2005-07-07 | — | — | WO | claimed |
| EP-1697353-A2 | ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS WITH AFFINITY FOR 5-HT1 RECEPTORS | Pfizer Products Incorporated (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050227980-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | PFIZER INC. | 2005-10-13 | — | — | US | disclosed |
| US-20050227981-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
| WO-2005061491-A2 | ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS WITH AFFINITY FOR 5-HT1 RECEPTORS | PFIZER PRODUCTS INC. (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227981-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | ARAF, MRPL21, ACSL3 | HSD11B1 2375/4885DRD2 166/4885DRD3 89/4885 |
| US-20050227980-A1 | Aralkyl and aralkylidene heterocyclic lactam and imides | ARAF, MRPL21, ACSL3 | HSD11B1 2375/4885DRD2 166/4885DRD3 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.