Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 17/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737234 | 0.77 | CCR4 (0.52) | CCR4 | |
| SCHEMBL5737779 | 0.70 | CCR4 (0.61) | CCR4 | |
| SCHEMBL16235458 | 0.60 | ATF1 (0.35) | CCR4MEN1KMT2A | |
| SCHEMBL5957166 | 0.59 | CCR4 (0.64) | CCR4 | |
| SCHEMBL5617350 | 0.59 | CCR5 (0.61) | CCR4CCR5 | |
| SCHEMBL5748366 | 0.59 | CCR4 (0.65) | CCR4 | |
| SCHEMBL5736940 | 0.58 | PDE4B (0.41) | MAPTMEN1KMT2A | |
| SCHEMBL6848031 | 0.57 | CCR4 (0.80) | CCR4 | |
| SCHEMBL8198000 | 0.56 | SMN1; SMN2 (0.46) | CCR4CCR5GAAMAPTMEN1 | |
| SCHEMBL17760483 | 0.56 | MCOLN3 (0.55) | CCR4HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633723-A1 | SULPHONAMIDE COMPOUNDS THAT MODULATE CHEMOKINE RECEPTOR ACTIVITY (CCR4) | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108690-A1 | SULPHONAMIDE COMPOUNDS THAT MODULATE CHEMOKINE RECEPTOR ACTIVITY (CCR4) | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | WO | claimed |