Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25297918 | 0.79 | ALDH1A1 (0.34) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL2147572 | 0.72 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL14946800 | 0.72 | ALDH1A1 (0.39) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| Hydrochloric Acid SCHEMBL15240864 | 0.71 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL881806 | 0.69 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL12310257 | 0.68 | ALDH1A1 (0.36) | GBA1ALDH1A1KDM4E | |
| SCHEMBL26633266 | 0.67 | GBA1 (0.33) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL5523044 | 0.66 | DGAT1 (0.48) | ALDH1A1KDM4EDGAT1 | |
| SCHEMBL31316741 | 0.66 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CPLAUGBA1 | |
| SCHEMBL13637055 | 0.66 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CPLAUGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654259-A1 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005005420-A1 | CYCLOPROPYL GROUP SUBSTITUTED OYAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2005-01-20 | — | — | WO | disclosed |