Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164158 | 0.88 | NPC1 (0.58) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1887833 | 0.79 | RAB9A (0.78) | NPC1RAB9AGSK3AGSK3BKMT2A | |
| SCHEMBL5165151 | 0.79 | MAPK14 (0.40) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5164299 | 0.78 | ALDH1A1 (0.61) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5162743 | 0.77 | NPC1 (0.67) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1889989 | 0.76 | RAB9A (0.53) | NPC1RAB9AGSK3AGSK3BKMT2A | |
| SCHEMBL5159025 | 0.76 | L3MBTL1 (0.45) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6158103 | 0.75 | NPC1 (0.40) | NPC1RAB9AGSK3AGSK3BKMT2A | |
| SCHEMBL6653278 | 0.73 | KMT2A (0.32) | KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL5159455 | 0.73 | ALDH1A1 (0.36) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622897-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Novartis AG (CH) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096797-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | NOVARTIS AG (CH) | 2004-11-11 | — | — | WO | disclosed |