Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.40 |
| ▸ | NPFFR1 | Q9GZQ6 | 5/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 5/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14265383 | 0.74 | ACHE (0.43) | OPRK1NPFFR1NPFFR2OPRD1OPRM1 | |
| SCHEMBL20446611 | 0.73 | SLC6A3 (0.40) | — | |
| SCHEMBL5736298 | 0.72 | POLB (0.39) | KMT2AMEN1TSHR | |
| SCHEMBL4036561 | 0.70 | FAAH (0.38) | OPRK1NPFFR1NPFFR2OPRD1MTNR1A | |
| SCHEMBL2494142 | 0.69 | SLC6A3 (0.40) | — | |
| SCHEMBL28506603 | 0.68 | — | — | |
| SCHEMBL28506600 | 0.68 | — | — | |
| SCHEMBL3644836 | 0.68 | NPFFR1 (0.36) | OPRK1NPFFR1NPFFR2OPRD1OPRM1 | |
| SCHEMBL1216003 | 0.67 | L3MBTL1 (0.40) | TSHRMAPK1 | |
| SCHEMBL29580884 | 0.67 | KDM4E (0.51) | KMT2ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |
| EP-1268418-B1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-14 | — | — | EP | disclosed |