⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20893213 | 0.73 | TNKS2 (0.50) | — | |
| SCHEMBL2918338 | 0.72 | IDO1 (0.33) | — | |
| SCHEMBL16432341 | 0.66 | SMN1; SMN2 (0.49) | — | |
| SCHEMBL2057008 | 0.60 | ALDH1A1 (0.40) | — | |
| SCHEMBL1450408 | 0.58 | L3MBTL1 (0.34) | — | |
| SCHEMBL6244145 | 0.55 | LOXL2 (0.31) | — | |
| SCHEMBL8402940 | 0.54 | TNKS2 (0.51) | — | |
| SCHEMBL2928704 | 0.54 | HCAR2 (0.53) | — | |
| SCHEMBL20876092 | 0.54 | TNKS2 (0.50) | — | |
| SCHEMBL19521479 | 0.54 | PSMB8 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455779-B1 | INDOLYLALKYLAMINE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH CORP (US) | 2006-08-09 | — | — | EP | disclosed |
| US-7022701-B2 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| US-6770642-B2 | FOR USE IN TREATMENT OF CNS DISORDERS SUCH AS ANXIETY, DEPRESSION, EPILEPSY, OBSESSIVE COMPULSIVE DISORDER, ATTENTION DEFICIT DISORDER, MIGRAINE, COGNITIVE MEMORY ENHANCEMENT, ALZHEIMER'S DISEASE | WYETH | 2004-08-03 | — | — | US | disclosed |