Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738562 | 0.93 | OPRM1 (0.54) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579551 | 0.83 | RECQL (0.57) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579758 | 0.80 | OPRM1 (0.58) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579883 | 0.73 | HTT (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| 2-Picolinic Acid SCHEMBL5740572 | 0.70 | RAB9A (0.52) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL5751520 | 0.70 | OPRM1 (0.58) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579810 | 0.70 | LTA4H (0.68) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL580192 | 0.69 | MEN1 (0.60) | OPRM1OPRD1OPRK1ALDH1A1LMNA | |
| SCHEMBL579606 | 0.69 | OPRM1 (0.65) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579444 | 0.68 | OPRM1 (0.60) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735268-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092836-A1 | OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-10-06 | — | — | WO | disclosed |