Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506707 | 0.84 | TSHR (0.40) | TSHRKMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10277484 | 0.75 | TSHR (0.40) | TSHRKMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10227666 | 0.70 | PDK2 (0.44) | TSHRKMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL15773718 | 0.64 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA7CA14 | |
| SCHEMBL22535940 | 0.64 | ALDH1A1 (0.48) | KMT2ASMN1; SMN2MEN1ALDH1A1POLB | |
| SCHEMBL11946799 | 0.64 | HTR7 (0.38) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL15013037 | 0.64 | SMN1; SMN2 (0.56) | KMT2ARAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7850276 | 0.64 | RIPK1 (0.49) | RAB9ASMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL16176470 | 0.62 | CA1 (0.51) | TSHRPOLBCA1CA2CA7 | |
| SCHEMBL8220431 | 0.62 | MMP13 (0.55) | RAB9ASMN1; SMN2ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720836-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005082859-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-09 | — | — | WO | disclosed |