Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739206 | 0.88 | — | — | |
| SCHEMBL2892992 | 0.88 | RXRA (0.39) | RXRAGRIN1GRIN2BMAPTMAPK1 | |
| SCHEMBL5740464 | 0.79 | RXRA (0.38) | RXRAGRIN1GRIN2B | |
| SCHEMBL5739060 | 0.79 | MAPT (0.43) | RXRAGRIN1GRIN2BMAPT | |
| SCHEMBL2895280 | 0.77 | RXRA (0.40) | RXRAGRIN1GRIN2BMAPTMAPK1 | |
| SCHEMBL2889382 | 0.76 | DDR1 (0.31) | RXRAGRIN1GRIN2B | |
| SCHEMBL2895208 | 0.76 | RXRA (0.35) | RXRAGRIN1GRIN2BMAPT | |
| SCHEMBL5741959 | 0.74 | PKM (0.38) | MAPT | |
| SCHEMBL2889151 | 0.73 | RXRA (0.34) | RXRAGRIN1GRIN2BMAPTMAPK1 | |
| SCHEMBL5740508 | 0.71 | HPGD (0.34) | MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |