Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895280 | 0.90 | RXRA (0.40) | RXRAGRIN1GRIN2BNPC1LMNA | |
| SCHEMBL5739224 | 0.84 | NOTUM (0.37) | KDM4ENOTUM | |
| SCHEMBL2892992 | 0.76 | RXRA (0.39) | RXRAGRIN1GRIN2BLMNA | |
| SCHEMBL2488620 | 0.74 | TLR8 (0.43) | RXRAGRIN1GRIN2BLMNAKMT2A | |
| SCHEMBL27669088 | 0.74 | KIF11 (0.39) | GRIN2BLMNAFFAR4KDM4EKMT2A | |
| SCHEMBL2889384 | 0.73 | RXRA (0.36) | RXRAGRIN1GRIN2BNPC1LMNA | |
| SCHEMBL5741042 | 0.72 | MAPT (0.51) | NPC1LMNARAB9AKDM4EKMT2A | |
| SCHEMBL2895031 | 0.71 | RXRA (0.39) | RXRAGRIN1GRIN2BNPC1LMNA | |
| SCHEMBL2893736 | 0.71 | ALDH1A1 (0.50) | LMNAKDM4E | |
| SCHEMBL5740390 | 0.71 | LMNA (0.34) | RXRAGRIN1GRIN2BNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |