Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844236 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL31148323 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL7784647 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL4309273 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL27780320 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL10756135 | 0.80 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL29975243 | 0.80 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL3631215 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL20342825 | 0.79 | TSHR (0.55) | ALDH1A1KDM4ELMNAMAPTMAPK1 | |
| SCHEMBL27708037 | 0.79 | MAPT (0.43) | ALDH1A1KDM4ELMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100376581-C | [1,4] diazocino [7,8, 1-hi ] indole derivatives as antipsychotic and antiobesity agents | WYETH CORP (US) | 2008-03-26 | — | — | CN | disclosed |
| CN-101076526-A | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors | NICHOLAS PIRAMAL INDIA LTD (IN) | 2007-11-21 | — | — | CN | disclosed |
| CN-101003538-A | [1,4]diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH CORP (US) | 2007-07-25 | — | — | CN | disclosed |
| EP-1497296-B1 | [1,4]DIAZOCINO[7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH CORP (US) | 2006-03-22 | — | — | EP | disclosed |
| US-7012089-B2 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH (US) | 2006-03-14 | — | — | US | disclosed |
| CN-1662539-A | [1,4] diazocino [7,8, 1-hi ] indole derivatives as antipsychotic and antiobesity agents | WYETH CORP (US) | 2005-08-31 | — | — | CN | disclosed |
| EP-1497296-A1 | 1,4 DIAZOCINO 7,8,1-hi INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH | 2004-02-19 | — | — | US | disclosed |
| WO-2003091257-A1 | [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | HTR1A, HTR2C, HTR1D | ALDH1A1 250/4885KDM4E 2302/4885LMNA 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.