Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 16/20 | 0.51 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959159 | 0.91 | KIF11 (0.60) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5740939 | 0.87 | KIF11 (0.47) | KIF11KIF23MAPT | |
| SCHEMBL3958220 | 0.86 | KIF11 (0.63) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3966803 | 0.86 | KIF11 (0.68) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3959566 | 0.84 | KIF11 (0.59) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3957584 | 0.84 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3960546 | 0.82 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5246236 | 0.81 | KIF11 (0.52) | KIF11KIF23 | |
| SCHEMBL3961576 | 0.81 | KIF11 (0.57) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL6209979 | 0.81 | KIF11 (0.54) | KIF11KIF23MAP1LC3BKCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |